Diabetes Mellitus Reduce Activity of Human Udp- Glucuronosyltransferase 2b7 (ugt 2b7) in Liver and Kidney Leading to Decreased Formation of Mycophenolic Acid Acyl- Glucuronide Metabolite
نویسندگان
چکیده
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 125 Fogarty Hall, 41 Lower College Road, Kingston, RI 02881 (M.D., F.A.); Comparative and Molecular Pharmacogenomics Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111 (M.H.C., S.H.). DMD # 36608 DMD Fast Forward. Published on December 1, 2010 as doi:10.1124/dmd.110.036608
منابع مشابه
Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite.
Mycophenolic acid (MPA) is an immunosuppressive agent commonly used after organ transplantation. Altered concentrations of MPA metabolites have been reported in diabetic kidney transplant recipients, although the reason for this difference is unknown. We aimed to compare MPA biotransformation and UDP-glucuronosyltransferase (UGT) expression and activity between liver (n = 16) and kidney (n = 8)...
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